所指示的分类、所代表的人称、引导从句时可修饰的成分不同。Who指的是人，whose既可以指人，也可以指物。Who做主格，whose只能做宾格。Who引导的从句中，who只能代表人，而whose可修饰从句（定于从句）中的主语、宾语、介词宾语等不同成分。
I saw a man shouting at a driver whose car was blocking the street.
我看见一个男人正朝一个司机叫嚷，他的车把街道堵塞了。
Whose daughter is she?
她是谁的女儿？
I can't remember whose idea it was for us to meet again.
我记不清我们再次会面是谁的主意了。
Whose handwriting is this? Can you identify it?
这是谁的笔迹，你辨认得出来吗？
Who's there?
谁在哪儿？
Police have not been able to find out who was responsible for the forgeries
警方还未能查明谁是这些造假案的元凶。
There are those who eat out for a special occasion, or treat themselves
有些人会在特殊的日子或犒劳自己时出去吃饭。
Who is the least popular man around here?
这里谁最不受欢迎？