Nonsense-mediated mRNA decay
Because mRNAs primarily function as templates for protein synthesis, it is logical that cells have evolved translation dependent quality-control mechanisms to dispose of defective mRNAs that synthesize abnormal proteins. NMD, which occurs in all eukaryotes that have been studied, eliminates mRNAs that prematurely terminate translation. This mechanism dampens the potentially toxic effects of defective transcripts that are routinely generated during gene expression. Downregulating the essential NMD factor up-frameshift 1 (UPF1) using short interfering RNA (siRNA) upregulates ~5% of properly functioning transcripts in HeLa cells. A similar percentage (~4%) is upregulated using siRNA targeting the UPF2 NMD factor. Thus, a substantial number of physiologic cellular transcripts are likely either to be direct NMD targets or to be downregulated by a direct NMD target, suggesting that NMD functions in cellular processes in addition to quality control.
翻译器的别来 忘了说
看的出来是自己翻的 但是好多地方比我翻的都差 你毕竟是没学这个专业的 有这样的水平已经不错了 我还是靠自己把 只能自己慢慢琢磨了 主要是专业属于翻不出来
要是这样翻 老师看了不要抽我一顿呀
追答那要怎么办呢
追问算了 自己翻 估计没人翻的出 走捷径看来不行
追答哦哦 对不起啦
老师 国家导弹防御系统这个怎么都出来了 还是靠自己了
追答NMD不知在生物学上是什么意思呀!
自己不是学生物专业的学生啊。