in spite of和despite的区别
一、读音不同
in spite of 英[ɪn spaɪt ɒv] 美[ɪn spaɪt əv]
despite 英[dɪˈspaɪt] 美[dɪˈspaɪt]
二、词性不同
in spite of 是介词短语，意为尽管;
despite
作介词时候，意为即使; 尽管; 尽管(自己)不愿意;
作名词时候意为怨恨; 恶意; 轻蔑; 侮辱;
三、侧重点不同
In spite of侧重于更侧重于描述客观事实，In spite of后面一半加名词、代词或者从句。
例如：In spite of the travelling and the late night, she did not feel tired.
尽管旅途劳顿，而且睡得很晚，她并没觉得累。
despite更侧重于描写主观意识。
例如：Despite our attempts to break it, the lock would not yield.
这把锁我们砸也砸不开。
四、双语例句
in spite of
1、In spite of what happened, he never lost the will to live.
尽管如此遭遇，他从未丧失活下去的意志。
2、In spite of his age, he still leads an active life.
尽管年事已高，他依旧过着一种忙碌的生活。
3、She is still very active, in spite of her advancing years.
她尽管年事渐高，仍然十分活跃。
4、They went swimming in spite of all the danger signs.
他们无视所有那些危险水域告示牌，还是去游泳了。
5、The Derby will be run in spite of the bad weather.
尽管天气恶劣，德比马赛仍将举行。
despite
1、But despite the best, most comprehensive plans, systems can fail.
但是即使采用了最好的、最综合的方案，系统还是可能崩溃。
2、Despite pain, I will still be there.
即使历尽艰辛磨难，我仍会在你身边。
3、Despite strong opposition, the ruling party carried the day.
尽管遭到强烈反对，执政党还是获胜了。
4、Despite the power cuts, the hospital continued to function normally.
尽管供电中断，医院继续照常运作。
5、Despite her earnest efforts, she could not find a job.
尽管她已尽心竭力，但是仍然找不到工作。