The first problem is that there is not atmosphere surrounding the pllanet.As a result,the space radiocation can hurt us easly.So we have to wear a type of clothes which is designed spically whenever we are in the open air.
The second problem is climate.In Mars,the average temperature is -60 degrees,and sometimes it can be -140 degrees. However,we can wear more clothes and eat more calory to keep warm.
The third problem is the oxygen and water whithout which we can't live.As you knowen there is plenty of iron oxide in the soil.So I think we can invent a method of iron oxide reduction.
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