have trouble with sth和have trouble in sth的区别有如下几点：
have trouble（ in 可以省略）doing sth 在做某事方面有困难, 费事，后面习惯接
动名词作宾语
例句：
I have some trouble (in) reading the letter，for handwriting is very bad.
我读这封信很困难, 因为他的书写很差.
With the boy leading the way,we had no trouble finding the village.
由于有那个男孩领路，我们没费多大劲就找到了那所村庄。
have trouble with sth有病痛, 因…苦恼;在某方面有麻烦，后面习惯接名词、代词，
名词性短语例句：
She is having trouble with her teeth.
她牙齿痛.
He has some trouble with his English pronunciation.
他的英语发音有问题。
同…闹纠纷
We had trouble with our neighbors over the noise that they were making.
我们因邻居制造的噪音而与他们闹纠纷.